Feb 22, 2008
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Category:1999 video games
Category:Association football video games
Category:Video games developed in the United Kingdom
Category:Video games set in England
Category:Windows games
Category:Windows-only games
Category:Video games scored by David Whittaker
Category:Multiplayer and single-player video games
Category:Sega video games
Category:Video games with expansion packsBiphasic action of xenon on norepinephrine release in the guinea pig isolated atria.
Biphasic effect of xenon on norepinephrine (NE) release were observed in spontaneously beating guinea pig isolated atria. In the presence of 2 mM potassium-rich Tyrode solution (69 mM NaCl, 2.7 mM KCl, 3 mM CaCl2, 1.8 mM MgCl2, 10 mM HEPES, and 12 mM glucose, pH 7.4), noradrenergic nerve stimulation induced NE release. Xenon (0.5-2%, 0.4 min of exposure) inhibited both early and late phases of NE release. Ethanol (1%) significantly inhibited both phases of NE release. At a concentration of 2%, xenon completely inhibited NE release. The inhibitory effect of xenon was antagonized by sodium bicarbonate. The presence of Ca2+ or Ba2+ in the Tyrode solution suppressed the inhibitory action of xenon. In the presence of 1 mM EGTA, neither xenon nor ethanol inhibited NE release. We conclude that xenon inhibits both phases of NE release in the guinea pig isolated atria. Xenon-induced inhibition of NE release appears to be due to the inhibition of the Ca2+/Ca2+ exchanger."The development ac619d1d87
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